Would authentication settings on SQL server 2008 R2 make any performance difference? ASP.net

Alright this is the first method

    public static string srConnectionString = "server=localhost; database=myDB; uid=sa; pwd=myPW;";

And this is the second method

    public static string srConnectionString = "server=localhost; database=myDB; integrated security=SSPI; persist security info=False; Trusted_Connection=Yes;";

Are there any performance difference or any other difference between these 2 connection strings?

This string is being used thousands of times per second on a global asp.net website : http://www.monstermmorpg.com/

Here my sql connection class any suggestion ?

using System;
using System.Data.Sql;
using System.Data.SqlClient;
using System.Data;

public static class DbConnection
{
    public static string srConnectionString = "server=localhost; database=myDB; uid=sa; pwd=myPW;";

    public static DataSet db_Select_Query(string strQuery)
    {
        DataSet dSet = new DataSet();
        if (strQuery.Length < 5)
            return dSet;
        try
        {
            using (SqlConnection connection = new SqlConnection(srConnectionString))
            {
                connection.Open();
                using (SqlDataAdapter DA = new SqlDataAdapter(strQuery, connection))
                {
                    DA.Fill(dSet);
                }
            }
            return dSet;
        }
        catch
        {
            using (SqlConnection connection = new SqlConnection(srConnectionString))
            {
                if (srConnectionString.IndexOf("select Id from tblAspErrors") != -1)
                {
                    connection.Open();
                    strQuery = strQuery.Replace("'", "''");

                    using (SqlCommand command = new SqlCommand("insert into tblSqlErrors values ('" + strQuery + "')", connection))
                    {
                        command.ExecuteNonQuery();
                    }
                }
            }
            return dSet;
        }
    }

    public static void db_Update_Delete_Query(string strQuery)
    {
        if (strQuery.Length < 5)
            return;
        try
        {
            using (SqlConnection connection = new SqlConnection(srConnectionString))
            {
                connection.Open();
                using (SqlCommand command = new SqlCommand(strQuery, connection))
                {
                    command.ExecuteNonQuery();
                }
            }
        }
        catch
        {
            strQuery = strQuery.Replace("'", "''");
            using (SqlConnection connection = new SqlConnection(srConnectionString))
            {
                connection.Open();
                using (SqlCommand command = new SqlCommand("insert into tblSqlErrors values ('" + strQuery + "')", connection))
                {
                    command.ExecuteNonQuery();
                }
            }
        }
    }
}

Browser based Pokemon Style MMORPG Game Developer Used asp.net 4.0 routing at it'sMonsters